Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study

Abstract Background Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) the lower limb, but predictors PTS are not well established. We aimed to examine in patients with long-term following DVT. Methods During 2006–09, 209 first time acute upper femoral or iliofemoral DVT were randomized receive either additional catheter-directed thrombolysis conventional therapy alone. In 2017, 170 still-living participants invited participate cross-sectional follow-up study. absence gold standard diagnostic test, was defined line clinical practice by four mandatory, predefined criteria: 1. An objectively verified DVT; 2. Chronic complaints (> 1 month) leg; 3. Complaints appeared after and 4. alternative diagnosis unlikely. Possible identified multivariate logistic regression. Results Eighty-eight (52%) included 8–10 years index DVT, 44 (50%) diagnosed criteria. Younger age higher baseline Villalta score found be independent PTS, i.e., OR 0.96 (95% CI, 0.93–0.99), 1.23 1.02–1.49), respectively. Lack patency at six months significant bivariate analysis, did prove adjustments. Conclusions follow up high younger PTS.